Squamous cell carcinoma

The second most common skin cancer, arising from the keratinocytes of the epidermis. It grows faster than basal cell carcinoma and spreads to lymph nodes in a small proportion of cases, particularly when large, thick, on the ear or lip, or in immunosuppressed people. Most are cured by excision.

Related terms

• Condition

  Basal cell carcinoma

  The most common skin cancer, arising from the basal cells of the epidermis. It grows slowly, is caused mainly by sun exposure, and very rarely spreads elsewhere, but it keeps invading local tissue if untreated. Usually cured by excision with a margin of normal skin.

• Glossary

  Surgical margin

  The rim of normal-looking tissue removed around a tumour so that its microscopic extensions are included. The clinical margin is measured on the skin before excision; the histological margin is the distance from the tumour to the cut edge under the microscope, usually reported as clear (at least 1 mm), close (under 1 mm) or involved.

Articles mentioning this term

1. Patient information · 26 September 2026

   Skin cancer surgery

   What basal cell and squamous cell carcinoma are, why excision is the usual treatment, what margins mean, how wounds are closed, and what recovery involves.

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