Diathesis

Constitutional predisposition to a more aggressive disease course and higher recurrence risk. The Hindocha 2006 modification of the original Hueston 1963 diathesis adds male sex and onset before age 50 to the original four features (Northern European descent, bilateral disease, ectopic disease, family history); the cumulative count predicts recurrence.

Related terms

• Condition

  Dupuytren's disease

  Benign progressive fibroproliferative disorder of the palmar and digital fascia, classified by WHO 2020 as a palmar-type fibromatosis. Characterised by myofibroblast-driven formation of nodules and cords in the palmar aponeurosis, leading to progressive flexion contracture of the digits, most commonly the ring and little fingers.

• Condition

  Garrod's pads

  Knuckle pads at the dorsal aspect of the proximal interphalangeal joints, an ectopic manifestation of the Dupuytren diathesis. Histologically related to the palmar disease and a recognised diathesis criterion.

• Condition

  Ledderhose disease

  Plantar fibromatosis — a benign fibroproliferative disorder of the plantar fascia, histologically related to Dupuytren's disease and sharing the myofibroblast-driven mechanism. A recognised ectopic manifestation of the Dupuytren diathesis.

Articles mentioning this term

1. Expert blog · 5 May 2026

   Choroba Dupuytrena — leczenie operacyjne

   Aponeurotomia igłowa i fasciektomia ograniczona w pierwotnym leczeniu choroby Dupuytrena — przegląd dowodów, anatomia patologiczna pasm jako predyktor wyboru techniki, definicja nawrotu, polski kontekst refundacyjny.

2. FESSH preparation · 5 May 2026

   Dupuytren's disease

   An expert synthesis of Dupuytren's disease — anatomy, the McFarlane cord pattern, the contemporary treatment landscape after the European withdrawal of collagenase, and the parallel consensus definitions of recurrence — for FESSH candidates and consultant peers.

3. Patient information · 5 May 2026

   Dupuytren's disease

   A plain-language guide to Dupuytren's disease — what it is, what causes it, how it is diagnosed, and the contemporary treatment options including needle fasciotomy and limited fasciectomy. Written for patients by a consultant hand surgeon.

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