Myofibroblast

Specialised contractile fibroblast expressing α-smooth muscle actin, responsible for the cellular contraction of the involutional phase of Dupuytren's disease. The cell type targeted by anti-TNF therapy in the RIDD trial. Population reactivation from residual proliferative foci is the cellular substrate of recurrence.

Articles mentioning this term

1. FESSH preparation · 5 May 2026

   Dupuytren's disease

   An expert synthesis of Dupuytren's disease — anatomy, the McFarlane cord pattern, the contemporary treatment landscape after the European withdrawal of collagenase, and the parallel consensus definitions of recurrence — for FESSH candidates and consultant peers.

← Back to glossary