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Glossary Investigation

Genome-wide association study

Hypothesis-free statistical interrogation of single-nucleotide polymorphisms across the genome for association with disease phenotype. The foundational GWAS in Dupuytren's disease is Dolmans 2011 (New England Journal of Medicine), identifying nine susceptibility loci, six harbouring Wnt-pathway genes.

Articles mentioning this term

  1. FESSH preparation

    Dupuytren's disease

    An expert synthesis of Dupuytren's disease — anatomy, the McFarlane cord pattern, the contemporary treatment landscape after the European withdrawal of collagenase, and the parallel consensus definitions of recurrence — for FESSH candidates and consultant peers.

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